Springbok bruiser Ruan Venter runs out for his 50th international appearance for the franchise and will be eager to impose his physicality against the tournament's defending champions.
Van Rooyen's men will be hoping to put last week's nail-biting 20-17 loss to Cardiff behind them, with a renewed focus towards a play-off finish in what remains a congested log table.
Speaking from Glasgow this week, tight head prop Asenathi Ntlabakanye believes capatilising on opportunities at key moments could have a huge impact on end result at the Scotstoun Stadium.
"Last week was a missed opportunity, we reviewed our game and we played really well," said Ntlabakanye.
"Just being clinical at the finishing stages, that's been a work-on this week â- finishing opportunities when we get into those zones."
Fondly known as the 'Jozi Bulldozer', the man who hails from Plettenburg Bay in the Western Cape, believes adapting to conditions in Europe is key, especially when facing a championship side such as Glasgow at home.
"Here in Europe, it's a bit different, there's a lot of things that factor into the end result, in that if you don't really capitalise, the home team knows how to play the conditions. So we need to be better in that aspect," he concluded.
There is only one change on the bench, which sees Rynardt Jonker replacing Henco van Wyk. The explosive centre returns home after sustaining a foot injury against Cardiff Rugby.
Kick-off is on Saturday at 21:35.
Lions - 15 Quan Horn, 14 Richard Kriel, 13 Manuel Rass, 12 Marius Louw, 11 Edwill van der Merwe, 10 Gianni Lombard, 9 Nico Steyn, 8 Francke Horn (c), 7 Ruan Venter, 6 JC Pretorius, 5 Darrien Landsberg, 4 Ruben Schoeman, 3 Asenathi Ntlabakanye, 2 PJ Botha, 1 Juan Schoeman.
Replacements: 16 Franco Marais, 17 SJ Kotze, 18 RF Schoeman, 19 Ruan Delport, 20 Siba Qoma, 21 Layton Horn, Â 22 Jarod Cairns, 23 Rynardt Jonker.