Australia allrounder Cameron Green is unlikely to be risked for the second Test against the Proteas, that starts in Gqeberha on Sunday, as he recovers from an abdominal strain.
Aiden Markram battled for almost six hours at the crease but a career-best bowling effort from Josh Hazlewood saw Australia complete a 214-run win against the Proteas in the first Test in Durban.
The Proteas will face a battle on the final day to save the opening Test against Australia in Durban, going to stumps on 102-4 after being set a target of 421.
Australia have earned a 139-run lead over South Africa after bowling out the lacklustre hosts for 284 runs in their first innings at Kingsmead Stadium on Sunday.
Australia will welcome Josh Inglis back into their squad ahead of the second Test against South Africa as the wicketkeeper-batter continues his recovery from a fractured finger.
Matt Renshaw struck a majestic career-best century before Australia took an early wicket to put the visitors on top after two days of the first Test against the Proteas at Kingsmead.