Carlos Alcaraz is still on course for a three-peat at Indian Wells after a dominant 6-2, 6-4 victory over Denis Shapovalov in the third round.
Having lost his last three matches, the normally imperious Novak Djokovic in the midst of a rare poor patch of form.
Novak Djokovic fell at the first hurdle of Indian Wells as he slumped to a shock defeat to Botic van de Zandschulp on Saturday.
Carlos Alcaraz cruised to a 6-4 6-2 win against France's Quentin Halys to get his Indian Wells title defence underway.
Jannik Sinner's coach Darren Cahill claims he has handled his positive test and subsequent ban like a "mature young man".
Stefanos Tsitsipas has returned into the top 10 of the world rankings after winning his maiden ATP 500 trophy at the Dubai Tennis Championships.