America's wait for a first home men's champion since Andy Roddick in 2003 will have to wait at least another year after Novak Djokovic defeated Ben Shelton in Friday's semi-finals.
Despite losing the opening set to love, Aryna Sabalenka rallied to defeat home crowd favourite Madison Keys in the US Open semi-final on Thursday.
Coco Gauff earned a straight-set victory over Karolina Muchova to reach the US Open final, but her achievement was somewhat marred by a climate protest which disrupted the match.
As players suffered through 32C temperatures and high humidity at the US Open on Wednesday, Daniil Medvedev feared the worst.
Top seeds Aryna Sabalenka and Madison Keys made easy work of their respective quarter-final opponents at the US Open in New York on Wednesday.
Defending US Open champion Carlos Alcaraz is on track to defend his title after sweeping past Alexander Zverev to reach the semi-finals on Wednesday.