The Sharks have named four debutants in their matchday 23 to face Cardiff in their United Rugby Championship fixture at Kings Park on Saturday.
The Lions handed Cardiff their eighth consecutive United Rugby Championship defeat on Saturday as they pulled off a 34-13 victory in Johannesburg.
The Lions take on Welsh side Cardiff Rugby in a crucial Round 16 match of the United Rugby Championship at Emirates Airline Park on Saturday.
Double World Cup-winning Springbok captain Siya Kolisi was on top form for Racing 92 on Saturday in their 48-26 victory over Cardiff in the Investec Champions Cup.
The Stormers suffered a heartbreaking last-minute defeat against Cardiff at the Arms Park after a late try from replacement prop Rhys Litterick handed the Welsh side a 31-24 victory.
The Bulls climbed to the top of the United Rugby Championship table after handing Cardiff a third defeat from four in an 18-12 win.