England captain Maro Itoje will earn his 100th international cap when he leads the side against Ireland at Twickenham on Saturday, with head coach Steve Borthwick making five changes to his lineup.
England's impressive 12-match unbeaten run came to a decisive end on Saturday as Scotland pulled off a stunning 31-20 upset at Murrayfield.
England opened their Six Nations campaign in emphatic fashion with a crushing 48-7 victory over Wales at Twickenham, underlining their credentials as chief challengers.
England head coach Steve Borthwick named his 36-man Six Nations squad with three uncapped players and no Owen Farrell.
England's backline depth is set for a major boost next year, after World Rugby granted a special exemption for South African-born utility back Benhard Janse van Rensburg.
England head coach Steve Borthwick has made six changes to his starting line-up for their Autumn Nations Series Test against Argentina at Twickenham on Sunday.