The world champion Springboks produced another performance for the ages as they overcame a red card to leave France stunned and empty-handed in Paris, running out 32-17 winners.
France flyhalf Romain Ntamack is bracing for a direct showdown with breakout Springbok star Sacha Feinberg-Mngomezulu, a player he openly admires.
France head coach Fabien Galthie has dropped his captain and named Gael Fickou as the leader of the matchday 23 to face the Springboks in Paris on Saturday.
Antoine Dupont looks set to miss the November internationals as he continues his recovery from a serious knee injury.
New Zealand sealed a 3-0 series sweep after overcoming a determined France side 29-19 at FMG Stadium Waikato on Saturday.
Gael Fickou is set to lead a severely understrength French squad on their tour to New Zealand.