Glasgow coach Franco Smith will welcome back several key players - including former Sharks star Henco Venter - as his side gears up for a quarter-final showdown with the Stormers at Scotstoun Stadium.
The Bulls became the first South African team to win at Scotstoun Stadium after a dramatic and physically bruising 26-19 URC victory over the Glasgow Warriors.
Bulls boss Jake White has made several changes to his team for a top-of-the-table clash against the Glasgow Warriors in their United Rugby Championship match on Friday.
Lions coach Ivan van Rooyen reflected on their difficult time in Europe, where they lost three games across two competitions.
Reigning United Rugby Championship title holders Glasgow Warriors were ruthless against the visiting Lions, winning 42-0 on Saturday.
The Stormers faded late as the defending URC champions Glasgow Warriors claimed a 28-17 victory in Stellenbosch.