Sharks coach John Plumtree is without five of his Springboks for their United Rugby Championship match against Ospreys on Friday.
Springbok and Sharks scrumhalf Grant Williams will be sidelined for the next few weeks as he recovers from a neck injury that has flared up once again.
Rassie Erasmus is set to assess his playmaking options after two Springbok scrumhalves suffered injuries while playing for their respective teams.
Sharks boss John Plumtree gave injury updates on Springbok stars Eben Etzebeth, Aphelele Fassi and Grant Williams.
Springbok captain Siya Kolisi once again leads the Sharks this weekend when they play their final Champions Cup pool game against Bordeaux Begles at the Stade Chaban-Delmas in France.
With the Springboks leading the way on the field, rugby was the big winner off the field at the annual South African Sport Industry Awards this week.