Tottenham will be without injured forward Timo Werner when they travel to his former club Chelsea on Thursday, while Ben Davies is also out until the end of the season.
Chelsea defender Thiago Silva has announced his planned departure from the club at the end of the season, after more than 150 appearances.
Chelsea's stoppage-time winner was ruled out by VAR in their 2-2 draw with Aston Villa in their Premier League clash at Villa Park on Saturday night.
Mauricio Pochettino insists he is happy at Chelsea despite recent defeats by Arsenal and Manchester City that have cast a shadow over his team's recent revival.
Enzo Fernandez will miss the remainder of Chelsea's season after undergoing surgery on a groin problem on Thursday.
Mikel Arteta was full of praise for two-goal hero Kai Havertz after Arsenal moved three points clear at the top of the Premier League with a 5-0 hammering of Chelsea.