Barcelona defeated Real Madrid in El Clasico and move 12 points clear at the top of La Liga.
Atletico Madrid were comfortable 3-0 winners over struggling Valencia in the highlight of Saturday's La Liga action.
Real Madrid's star striker, Karim Benzema, is expected to play a pivotal role against Barcelona on Sunday despite being injured.
Real Madrid boss Carlo Ancelotti admits that he has no idea what lies ahead against Liverpool in the Bernabeu clash.
Alvaro Morata scored a late winner to hand Atletico Madrid all three points in a narrow 1-0 win over Girona in LaLiga.
Manchester United beat Real Betis in their Europa League clash at Old Trafford on Thursday night.