Barcelona defeated Real Madrid in El Clasico and move 12 points clear at the top of La Liga.
Real Madrid's star striker, Karim Benzema, is expected to play a pivotal role against Barcelona on Sunday despite being injured.
Chelsea face 14-time winners Real Madrid and Manchester City are up against Bayern Munich in the Champions League quarter-finals.
Real Madrid goalkeeper Thibaut Courtois believes the club's continued success in Europe can offset the power of the Premier League.
Karim Benzema helped Real Madrid seal victory against Liverpool in the Champions League but limped away with an injury.
Liverpool's impossible job against Real Madrid in the Bernabeu proved exactly that as there was no dramatic comeback and a 1-0 defeat saw them exit the Champions League without much of a fight.