Proteas skipper Temba Bavuma showcased his batting prowess with a valiant century, but it was Australia who fought to secure the ODI victory.
Aiden Markram has given credit to Donovan Ferreira following his 48 off 21 balls in his debut for the Proteas in their final T20 series loss against Australia in Durban.
Australia all-rounder Glenn Maxwell is adopting a cautious approach as he looks to recover from an ankle injury in time for the upcoming ICC World Cup in India.
Australia completed a whitewash over South Africa with a five-wicket victory in the third and final T20 international at Kingsmead on Sunday.
The Proteas will hand the gloves to Tristan Stubbs, who gets the nod at senior international level for the first time, against Australia at Kingsmead on Wednesday.
The best teams in the 50-over game are set to descend on India for the Cricket World Cup, with each side looking to wrestle the trophy away from reigning champions England, who won the competition on their own turf back in 2019.