Jordan Cox scored a quickfire 55 off 35 balls at a packed Malahide, guiding England to a comfortable six-wicket win and sealing the T20 series 2-0 after restricting Ireland to 154.
Phil Salt smashed 89 from 46 balls to help England to a four-wicket victory against Ireland in the first of three T20Is in Dublin on Wednesday.
Ireland claimed just their second ODI victory over the Proteas as half-centuries from Paul Stirling and Harry Tector contributed to a 69-run victory in sweltering Abu Dhabi on Monday.
The Proteas claimed a dominant 174-run victory over Ireland in the second ODI in Abu Dhabi, securing an unassailable 2-0 lead in the three-match series.
The Proteas romped to a 139-run victory over Ireland in the first ODI in Abu Dhabi on the back of Ryan Rickelton and Tristan Stubbs starring with the bat and a clinical bowling performance.
Ross Adair propelled Ireland to victory with a magnificent century in the second and final T20 International against South Africa at the Sheikh Zayed Stadium in Abu Dhabi on Sunday evening.