Reeza Hendricks and Ryan Rickelton made light work of Ireland in their first T20 International as they helped steer the Proteas to an eight-wicket victory with 14 balls to spare.
A battling counter-attack by George Dockrell and Mark Adair fell short as Ireland suffered a shock 12-run loss to Canada in their T20 World Cup clash in New York.
Ireland are set to "host" the Proteas for two T20Is and three ODIs in Abu Dhabi in late September and October.
Andy Balbirnie's unbeaten 58 helped Ireland seal a historic first Test win as they held their nerve to beat Afghanistan by six wickets in Abu Dhabi.
Sri Lanka made it four wins from four but were made to work hard for an 82-run win over previously unbeaten Scotland to top Group B at the World Cup Qualifiers.
Michael Leask blasted Scotland to a dramatic one-wicket victory in their opening World Cup qualifier fixture as Ireland's hopes were dealt a major blow despite Curtis Campher's brilliant century.