Ireland are set to "host" the Proteas for two T20Is and three ODIs in Abu Dhabi in late September and October.
Andy Balbirnie's unbeaten 58 helped Ireland seal a historic first Test win as they held their nerve to beat Afghanistan by six wickets in Abu Dhabi.
Sri Lanka made it four wins from four but were made to work hard for an 82-run win over previously unbeaten Scotland to top Group B at the World Cup Qualifiers.
Michael Leask blasted Scotland to a dramatic one-wicket victory in their opening World Cup qualifier fixture as Ireland's hopes were dealt a major blow despite Curtis Campher's brilliant century.
Debutant Josh Tongue claimed five wickets to help England beat Ireland inside three days at Lord's, but only after a record 163-run partnership between tailenders Mark Adair and Andy McBrine.
England are on the verge of a first victory of the home summer after record-breaking innings by Ollie Pope and Ben Duckett almost saw Ireland defeated inside two days at Lord's.