World number one Carlos Alcaraz has been knocked out of the National Bank Open after losing to American Tommy Paul for the second straight year in Toronto.
Chris Eubanks knocked out two seeded players before his epic Wimbledon run came to an end in a five-set thriller against Daniil Medvedev on Wednesday.
World number three Daniil Medvedev eased into his maiden Wimbledon quarter-final after Jiri Lehecka was forced to retire injured.
Daniil Medvedev has suggested that the heavier weighted balls used at the French Open played the biggest role towards his first-round French Open exit.
Second seed Daniil Medvedev was the first big casualty of the French Open after losing in five sets to Brazilian qualifier Thiago Seyboth Wild in the opening round.
Daniil Medvedev will overtake Novak Djokovic as world number two after completing his clay-court transformation with victory over Holger Rune to win the Italian Open.