The change sees Jarod Cairns join the back row alongside captain Francke Horn and Springbok Ruan Venter.
The front-row replacements feature Morgan Naude and Conrad van Vuuren, with Siba Qoma also making a return.
Recently announced Springbok Alignment Camp attendees Renzo du Plessis and Nico Steyn could also feature come Saturday.
The Lions also issued an injury update to clarify which players are unavailable for selection.
The players are: Bronson Mills, Rabz Maxwane, Ruhan Straeuli, Reinhardt Nothnagel, Erich Cronje, Raynard Roets, Rynhardt Jonker and Morne Brandon.
Lions: 15 Quan Horn, 14 Richard Kriel, 13 Henco van Wyk, 12 Marius Louw, 11 Edwill van der Merwe, 10 Gianni Lombard, 9 Morne van den Berg, 8 Francke Horn (captain), 7 Ruan Venter, 6 Jarod Cairns, 5 Darrien Landsberg, 4 Etienne Oosthuizen, 3 Asenathi Ntlabakanye, 2 PJ Botha, 1 Juan Schoeman
Replacements: 16 Jaco Visagie, 17 Morgan Naude, 18 Conraad van Vuuren, 19 Ruan Delport, 20 Sibabalo Qoma, 21 Renzo du Plessis, 22 Nico Steyn, 23 Manuel Rass.