Jaco Visagie will lead the Lions as they go in search of an unprecedented Challenge Cup Round-of-16 victory over Benetton in Monigo on Saturday.
The Cheetahs take on Auvergne Clermont in a knockout Challenge Cup encounter in France this Saturday.
The Sharks shift their focus towards the EPCR Challenge Cup knock-outs and a Round of 16 clash against Zebre Parma at Kings Park on Sunday.
The Cheetahs departed on Tuesday for their Challenge Cup Round of 16 clash against Clermont Auvergne.
Bulls Director of Rugby Jake White is both cautious and optimistic as he assesses South African teams' chances of achieving success in the Champions and Challenge Cups.
The Ospreys scored three tries in the last eight minutes to stun the Lions 28-38 in Johannesburg in their Challenge Cup clash on Sunday.