The Lions have received a welcome boost with the return to fitness of Springbok fullback Quan Horn and outside centre Henco van Wyk ahead of two crucial URC away fixtures and a Challenge Cup playoff.
The Round of 16 line-ups for the Champions Cup and Challenge Cup have both been confirmed after the conclusion of this weekend's pool stage action.
The Cheetahs are out of the Challenge Cup competition in Europe after suffering a chastening 68-21 defeat against Lyon in France on Saturday night.
The Bulls produced a dominant display to beat Stade Francais 48-7 at Loftus Versfeld and charge into the Challenge Cup playoffs.
The Lions are through to the knockout rounds of the Challenge Cup after making light work of the Dragons in a 60-10 victory at Ellis Park.
After a victory over Zebre Parma on Sunday, the Cheetahs travel to France to face Lyon Olympique Universitaire in Round 4 of the EPCR Challenge Cup.