Springbok forwards Frans Malherbe and Marvin Orie have been included in the Stormers team to face London Irish in Saturday's Heineken Champions Cup encounter at DHL Stadium.
The Cheetahs have lost the services of flanker Oupa Mohoje for the next three weeks after he was hit with a suspension for a high tackle.
Springbok star Lukhanyo Am has returned to full fitness and will be on the bench when the Sharks return to action in the Champions Cup against Bordeaux Bègles on Friday.
Clermont roared back in the second half to open their Champions Cup campaign with a 24-14 victory over the Stormers in France.
Toulouse scrumhalf Antoine Dupont has admitted that South African clubs' introduction into the Champions Cup had been "difficult to grasp".
Stormers head coach John Dobson is well aware of Clermont's threat at home ahead of his side's Champions Cup opener on Saturday.