Siya Kolisi leads the Sharks in one of the most eagerly anticipated rugby matches in recent times as they host Champions Cup title-holders Toulouse in Durban.
Bulls forward Jan-Hendrik Wessels is hoping to right the ship with his teammates in their Champions Cup clash in France this weekend.
The Sharks host Stade Toulouse at Hollywoodbets Kings Park in a third match of the Investec Champions Cup group stage on Saturday.
France captain Antoine Dupont looks set to add to his single appearance in the southern hemisphere as Toulouse head to South Africa to face the Sharks.
With a host of players currently sidelined and the depth of the squad being tested, the Stormers took some hard lessons from their Champions Cup clash with Harlequins in London.
South African coaches have raised alarms about demanding player schedules and travel pressures following a brutal weekend for their teams in the Champions Cup.