England head coach Steve Borthwick has made no less than nine changes to his matchday 23 that will face Italy in the Six Nations at the Stadio Olimpico in Rome on Saturday.
Ireland are awaiting further assessments on star winger James Lowe, who is recovering from a groin injury sustained during their recent win over England.
England's Six Nations title hopes were effectively ended after a record 42-21 defeat to Ireland at Allianz Stadium, Twickenham, with Ellis Genge apologising to supporters and admitting the squad had "believed the hype" after their opening-round win.
Ireland legend Brian O'Driscoll admits he was completely shocked by how Ireland was able to dismantle England at Twickenham in the Six Nations.
Ireland head coach Andy Farrell has axed Sam Prendergast for the Six Nations clash against England at Allianz Stadium, Twickenham, on Saturday.
Scotland have been dealt a setback ahead of their next Six Nations clash after three of the heroes from last weekend's epic victory over England returned to their clubs with injuries.