Alun Wyn Jones, the world's most-capped rugby union player, has announced his retirement from the international game.
Wales and Cardiff flanker Josh Navidi has been forced to announce his immediate retirement from rugby because of a serious neck problem.
Wales will be missing Liam Williams for Saturday's Six Nations clash with France due to a shoulder injury.
Wales star Taulupe Faletau says it is "hard to give your all" against the crushing contractual and financial backdrop that has engulfed Welsh regional rugby.
England posted a first statement win of the Steve Borthwick era as they heaped further misery on Wales with a 20-10 victory in Cardiff.
Warren Gatland is confident Wales' clash with England on Saturday will go ahead and hopes the dispute between his players and the Welsh Rugby Union will be resolved.