Wales star Taulupe Faletau says it is "hard to give your all" against the crushing contractual and financial backdrop that has engulfed Welsh regional rugby.
England posted a first statement win of the Steve Borthwick era as they heaped further misery on Wales with a 20-10 victory in Cardiff.
Warren Gatland is confident Wales' clash with England on Saturday will go ahead and hopes the dispute between his players and the Welsh Rugby Union will be resolved.
Alun Wyn Jones says the possibility of player strike action is "hard to deny" as Welsh rugby finds itself gripped by a professional contracts freeze.
Wales' professional players could consider strike action amid a new contracts freeze in Welsh rugby.
Warren Gatland has admitted Wales are in a bit of a hole as they bid to bounce back following successive heavy defeats in their opening two Six Nations matches.