Newcastle captain Bruno Guimaraes faces a lengthy spell on the sidelines after suffering a hamstring injury in the closing stages of the Magpies' 2-1 Premier League win over Tottenham Hotspur on Tuesday.
Newcastle United staged a thrilling turnaround to defeat 10-man Aston Villa 3-1 and secure their place in the fifth round of the FA Cup, with Sandro Tonali's double proving decisive.
Newcastle United overturned an early deficit to beat Aston Villa 3-1 in an FA Cup fourth-round tie marred by refereeing controversies.
Bruno Guimaraes and Lewis Miley will miss Saturday's FA Cup fourth-round tie, dealing Eddie Howe a significant double blow as Newcastle prepare to face Aston Villa at Villa Park.
Tottenham's relegation fears deepened after a 2-1 home defeat to Newcastle increased the pressure on head coach Thomas Frank and extended the club's alarming slide down the Premier League table.
Eddie Howe has reaffirmed his commitment to Newcastle United, insisting he would step aside if he ever felt he was no longer the right man to lead the struggling club.