Jaden and Jordan Hendrikse - the 36th set of Springbok brothers - have been paired at halfback for the season's final Test against Wales in Cardiff while Cameron Hanekom could make his debut.
The Sharks closed out the first part of their Currie Cup campaign with an emphatic victory and now get set for the final phase of the tournament's pool stages.
Springbok scrumhalf Jaden Hendrikse will make his long-awaited return from injury when he runs out for the Sharks XV in Sunday's Currie Cup clash with the Griquas in Durban.
The Sharks are set to head into the Challenge Cup final without two of their Springbok superstars.
The Sharks confirmed the signing of Lions pivot Jordan Hendrikse for the 2024/2025 season on Wednesday.
The Sharks impressed away from home with a 29-9 win over the Dragons at Rodney Parade as the Durban side cemented their position at the top of Pool One.