The Springboks paid the price for failure to take their chances as Andy Farrell's impressive Ireland side emerged 13-8 winners in Paris.
Henry Arundell plundered five tries as England overcame a frantic start to dismantle Rugby World Cup newcomers Chile with a 71-0 victory that continues their march towards the quarter-finals.
Portugal fell agonisingly short of a first Rugby World Cup victory as they drew 18-18 with Georgia after a dramatic conclusion in Toulouse.
Emiliano Boffelli was the difference-maker as Argentina survived a late charge to beat Samoa 19-10 and reignite their Rugby World Cup campaign.
Namibia captain Johan Deysel has apologised to Antoine Dupont following a head-on-head collision that has left the France star's Rugby World Cup campaign in doubt.
Ireland head coach Andy Farrell does not believe his side are favourites for Saturday's massive Rugby World Cup clash against the Springboks, despite being No 1 in the world.