The Lions have selected Springbok stars Morne van den Berg and Edwill van der Merwe alongside rookie flyhalf Sam Francis for Saturday's URC clash against the Stormers in Cape Town.
The Lions and Cheetahs will look to bounce back from a defeat and a draw respectively as they brace for this weekend's second round action in the European Challenge Cup.
The Lions' unbeaten United Rugby Championship (URC) record this season came to an end after a 24-6 loss to top of the table Leinster in Dublin on Saturday.
Flyhalf Kade Wolhuter has been included in Ivan van Rooyen's starting XV as the Lions travel to the Aviva Stadium to face Leinster in Round 6 of the United Rugby Championship.
It's a top-of-the-table clash when the United Rugby Champions only to undefeated teams - Lions and Leinster - go head to head on Saturday.
Rabz Maxwane scored a hat-trick as the Lions made it two wins from two in the United Rugby Championship with a 55-21 win over Edinburgh at Ellis Park.