The Lions' URC playoff hopes were dealt a blow in Wales on Friday as they suffered a narrow 20-17 defeat against Cardiff in wet and testing conditions.
There are no less than eight Springboks in the Stormers' starting line-up for their United Rugby Championship encounter with Scarlets in Llanelli on Saturday.
The Bulls have made personnel and positional changes for their round 13 United Rugby Championship clash against Irish outfit Leinster.
With star players returning, Stormers boss John Dobson is focused on securing a top-six finish in the URC ahead of their tour to the United Kingdom.
Zebre comes to Hollywoodbets Kings Park to face a confident Sharks side that is undefeated at home in the United Rugby Championship this season.
With the Bulls set to host Leinster in a top-of-the-table United Rugby Championship match on Saturday Leinster coach Jacques Nienaber is preparing for war.