Ireland boss Andy Farrell is optimistic most of his sidelined stars will be fit and firing for a crunch Murrayfield showdown with title rivals Scotland.
A disastrous opening 20 minutes ultimately proved costly for Scotland as their perfect start to the Six Nations campaign came to an end with a 32-21 defeat by France in Paris.
England posted a first statement win of the Steve Borthwick era as they heaped further misery on Wales with a 20-10 victory in Cardiff.
Tom Curry will play no part in the 2023 Six Nations after being ruled out for at least four weeks with a torn hamstring.
Alun Wyn Jones says the possibility of player strike action is "hard to deny" as Welsh rugby finds itself gripped by a professional contracts freeze.
England forwards coach Richard Cockerill has hit back at calls in New Zealand to outlaw the maul by declaring they will continue to use an important weapon in their arsenal.