Liverpool boss Arne Slot will miss his team's Carabao Cup encounter with Southampton on Wednesday, serving a touchline ban due to accumulating three bookings this season.
Tottenham Hotspur delivered a dominant performance to crush Southampton 5-0 at St Mary's Stadium on Sunday, ending a five-game winless streak in the Premier League.
Southampton were left frustrated on Friday night as VAR ruled out what could have been a decisive goal in their 1-1 draw against Brighton in the Premier League.
Liverpool have solidified their position at the top of the Premier League, eight points clear of Manchester City after a thrilling comeback victory against Southampton.
Trent Alexander-Arnold will miss Liverpool's Premier League clash with Southampton due to a hamstring injury, while Virgil van Dijk is ready to play.
While Southampton have struggled for points so far on their return to the Premier League, head coach Russell Martin believes there are still plenty of positives to take from the experience.