The Proteas fought to the bitter end but ultimately fell to a two-wicket defeat with two balls to spare against Pakistan in the first ODI in Faisalabad on Tuesday.
Dewald Brevis has been ruled out of the Proteas' three-match ODI series in Pakistan, that starts in Faisalabad on Tuesday, after suffering a low-grade shoulder muscle strain.
Pakistan cruised to a four-wicket victory against South Africa in the third T20 International at the Gaddafi Stadium on Saturday to claim the series 2-1.
Pakistan blew the Proteas away with the ball as they cruised to a nine-wicket victory in the second T20I in Lahore on Friday night.
Proteas batter David Bedingham has been ruled out for at least the next month after suffering a quadriceps muscle injury.
Reeza Hendricks struck a composed 60 off 40 balls before Corbin Bosch took four wickets to help the Proteas beat Pakistan by 55 runs in the first T20I in Rawalpindi.