West Indies held their nerve against a rampant Temba Bavuma to beat the Proteas by 48 runs in the second ODI in East London on Saturday.
The Proteas will look to test squad depth in the three-match ODI series against the West Indies that starts in East London on Thursday.
English county side Middlesex are on the lookout for a new overseas signing for 2023 after Proteas spinner Keshav Maharaj was forced to withdraw through injury.
Wayne Parnell and Tabraiz Shamsi have been drafted into the Proteas ODI squad for the series against West Indies as injury replacements.
The Proteas completed a comprehensive 284-run victory against the West Indies on the fourth day of the second Test at the Wanderers that also sealed a series clean sweep.
Sisanda Magala and Marco Jansen have earned their first national contracts after Cricket South Africa (CSA) announced a list of 20 players.