Proteas captain Temba Bavuma has been ruled out of the first Test against Bangladesh, starting on 21 October in Dhaka, after scans revealed a left tricep muscle strain.
Ireland claimed just their second ODI victory over the Proteas as half-centuries from Paul Stirling and Harry Tector contributed to a 69-run victory in sweltering Abu Dhabi on Monday.
Proteas captain Temba Bavuma will play no part in the final One Day International against Ireland in Abu Dhabi on Monday.
The Proteas claimed a dominant 174-run victory over Ireland in the second ODI in Abu Dhabi, securing an unassailable 2-0 lead in the three-match series.
The Proteas have suffered a major blow ahead of the Test tour to Bangladesh later this month after fast bowler Nandre Burger was ruled out due to a back injury.
Cricket South Africa has revealed that Proteas' spinner Tabraiz Shamsi has decided to opt out of his national contract, effective immediately.