Proteas captain Temba Bavuma will play no part in the final One Day International against Ireland in Abu Dhabi on Monday.
The Proteas claimed a dominant 174-run victory over Ireland in the second ODI in Abu Dhabi, securing an unassailable 2-0 lead in the three-match series.
The Proteas have suffered a major blow ahead of the Test tour to Bangladesh later this month after fast bowler Nandre Burger was ruled out due to a back injury.
Cricket South Africa has revealed that Proteas' spinner Tabraiz Shamsi has decided to opt out of his national contract, effective immediately.
The Proteas romped to a 139-run victory over Ireland in the first ODI in Abu Dhabi on the back of Ryan Rickelton and Tristan Stubbs starring with the bat and a clinical bowling performance.
The Proteas have selected three frontline spinners for the two Test matches in Bangladesh in October as coach Shukri Conrad unveiled the 15-man squad.