The 10-try triumph secured a fourth consecutive Test win for Steve Borthwick's side, underlining their growing momentum in the Six Nations, and, marking their largest-ever victory against their fierce rivals.
Maro Itoje set the tone early, powering over for Englandâs opening try, before 20-year-old flanker Henry Pollock stole the headlines with a brace on his debut.
Fly-half Fin Smith orchestrated the attack with precision, delivering accurate passes and controlling play with his kicking game.
Wingers Tom Roebuck and Tommy Freeman also played crucial roles, with Roebuck crossing after a long, looping pass from Smith, while Freeman became only the second player in Six Nations history to score in all five rounds of a single championship.
Will Stuart marked his 50th cap with a try, and Chandler Cunningham-South added his name to the scoresheet after replacing the injured Ollie Chessum.
For Wales, it was another disappointing outing in a season to forget. The defeat marked their 17th consecutive international loss and condemned them to a second successive Six Nations wooden spoon.
Centre Ben Thomas provided the only highlights for the hosts, scoring both of their tries.