Lock Jean Kleyn has played international rugby before but admits nothing compares to the prospect of making his debut for the Springboks.
Tom Hooper will make his debut at flank for the Wallabies against the Boks on Saturday, while head coach Eddie Jones has picked another three debutants on the bench.
Springbok coach Jacques Nienaber was forced to make a late change to his team for their opening Rugby Championship Test against the Wallabies in Pretoria on Saturday.
Springbok fullback Willie le Roux is back in South Africa after penning a new contract with the Blue Bulls.
Duane Vermeulen will lead the Springboks for the third time when they take to the field for their Rugby Championship opener against Australia at Loftus Versfeld on Saturday.
Springbok captain Siya Kolisi has issued another positive update as he continues his recovery from a knee injury.