Manchester City boss Pep Guardiola admits the John Stones injury is a big blow and will force his side to play "differently".
Casemiro is set to miss a key stretch of Manchester United's season after Erik ten Hag revealed the midfielder will be sidelined with a hamstring injury until after Christmas.
Kieran Trippier still has hope for Newcastle's Champions League campaign despite the crippling defeat to Borussia Dortmund.
Manchester City suffered a setback in their Champions League win over Young Boys on Tuesday, losing centre-back John Stones to injury.
Chelsea striker Nicolas Jackson promised to work even harder after his hat-trick earned boss Mauricio Pochettino a statement victory at former club Tottenham.
Mikel Arteta has stood by his VAR outburst following Arsenal's loss at Newcastle on Saturday and will continue to "talk loudly" until it improves.