Manchester City defender Nathan Ake will be sidelined for three months after undergoing foot surgery.
Pep Guardiola has claimed that the ball used in the FA Cup is "not right" after Manchester City struggled to convert chances during their 3-1 victory over Plymouth Argyle on Saturday.
Amad Diallo, the 22-year-old winger for Manchester United, will miss the remainder of the season after sustaining a season-ending ankle injury during training last month.
Kaoru Mitoma's injury cast a shadow over Brighton's 2-1 victory over Newcastle United in the FA Cup, as the winger was forced to hobble off in the 90th minute with a suspected knee injury.
Newcastle United's hopes of lifting their first major trophy since 1955 have taken a massive hit after winger Anthony Gordon was sent off for violent conduct in a 2-1 FA Cup fifth-round defeat to Brighton on Sunday.
Manchester United manager Ruben Amorim has informed his players to anticipate several departures at the end of the season as part of a squad overhaul.