Erik ten Hag has blamed injuries for ruining Donny van de Beek's spell at Manchester United.
Liverpool continue to battle on four fronts after Jakub Kiwiorr's own goal and a stoppage-time strike by Luis Diaz sent them through to the FA Cup fourth round with a 2-0 win at Arsenal.
Kevin De Bruyne made an eye-catching return and Phil Foden struck twice as holders Manchester City thrashed Huddersfield 5-0 in the FA Cup third round.
Crystal Palace and Everton will replay their FA Cup third-round clash after their Selhurst Park encounter ended in a goalless draw.
Erling Haaland has handed Manchester City a major injury boost after returning to training.
West Ham manager David Moyes admits it will be a blow to lose Mohammed Kudus for the Africa Cup of Nations.