Springbok head coach Rassie Erasmus has offered a positive injury update on star loosehead Ox Nche, but also admitted he wouldn't risk him if in doubt.
Bok lock RG Snyman said it would be a tough closing encounter against Wales as they look to secure a full house of wins in the November internationals for the first time since 2013.
The Springboks made it two wins from two on their end-of-year tour as they defeated a spirited England side 29-20 in front of a sold-out Twickenham.
Springbok captain Siya Kolisi says they are expecting nothing less than a full 80-minute battle against a wounded but dangerous England side in front of a sell-out 80,000-strong crowd at Twickenham on Saturday.
The Springboks are aware of the challenge presented by the short turnaround between their Sunday fixture with Scotland and Saturday's Test against England in London.
England lock Maro Itoje believes his side has what it takes to beat the Springboks on Saturday, calling it an opportunity to "take control of the narrative".