Tom Hooper will make his debut at flank for the Wallabies against the Boks on Saturday, while head coach Eddie Jones has picked another three debutants on the bench.
Springbok fullback Willie le Roux is back in South Africa after penning a new contract with the Blue Bulls.
Springbok captain Siya Kolisi has issued another positive update as he continues his recovery from a knee injury.
Wallabies prop Allan Alaalatoa knows it won't be easy against the Springboks on Saturday, regardless of who they select to start their Rugby Championship opener at Loftus Versfeld.
Flyhalf Jean Smith will return to his role as starting No 10 when South Africa take on Argentina at Athlone Stadium in their 2023 World Rugby Under-20 Championship in Cape Town on Tuesday.
South Africa's top schoolboys will have the chance to shine at the SA Rugby U18 Craven Week, which will be staged at Outeniqua Park in George next week.