The Irish Rugby Football Union has confirmed that stars Dan Sheehan and Craig Casey will miss the second Test against South Africa in Durban due to injury.
Ireland head coach Andy Farrell wants his players to avoid being "desperate" in their efforts to salvage a series draw in South Africa.
The Springboks produced several key moments of magic to defeat Ireland 27-20 at Loftus Versfeld and finally get the better of Andy Farrell's men.
Handre Pollard admits he can't wait to return to action for the Springboks in his first appearance since lifting the Rugby World Cup trophy in France.
Cheslin Kolbe says the Springboks will need to be accurate in their execution if they are to beat Ireland on Saturday - but also stressed the importance of enjoying the occasion.
Head coach Andy Farrell has named the Ireland match-day squad to face South Africa in Saturday's first Test at Loftus Versfeld Stadium.